The rare variants of the BSN and APBA1 genes are the first obesity-relat genes where the increas risk only occurs in adulthood. Moreover, genetic variations with such an impact on obesity risk have almost never been found before.
The researchers from the University of Cambridge us data from more than 500,000 people from the UK Biobank for something call exome sequencing. This genetic engineering technique sequences all protein-coding regions of genes. Sequencing is a technique that reads the code of DNA.
The British discover that genetic variants of the BSN gene, also known as Bassoon, can increase the risk of obesity sixfold. The gene variant also caus an increas risk of non-alcoholic fatty liver disease and type 2 diabetes. The Bassoon gene variants occur in 1 in 6,500 adults, so in the UK alone this amounts to around 10,000 people.
The Bassoon gene
Some people seem to get fat just by looking at a piece of cake, or so we sometimes say. That is of course not true, but it has been buy email database known for some time that there are genes that partly determine why some people gain weight more easily than others. However, there was little clarity about this until now.
Previous research has identifi some gene variants that already have an effect in childhood and work via leptin-melanocortin, which plays a key role in regulating hunger in the brain.
New mechanism discover
Although both BSN and APBA1 encode proteins in the brain. They are not known to be involv in the leptin-melanocortin ਇਹ ਵਧੇਰੇ ਵਿਕਰੀ ਦੇ ਮੌਕੇ ਪ੍ਰਦਾਨ ਕਰਦਾ ਹੈ. pathway. In addition, they are not link to childhood obesity.
That’s why the researchers, whose appear in Nature . Think they may have discover a new biological mechanism for obesity. Different ar numbers from those already known from previously identifi obesity genes. It’s likely that BSN and APBA1 play a role in the transmission of signals between brain cells. And that aging affects. The ability of people with these gene variants to control hunger.
